Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays

Elnager, Abuzar and Hassan, Rosline and Idris, Zamzuri and Mustafa, Zulkifli and Arfah, Nadiah Wan and Sulaiman, S. A. and Siew, Hua Gan and Abdullah, Wan Zaidah (2015) Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays. BioMed Research International, 2015 (627471). pp. 1-10. ISSN 2314-6133

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Abstract

Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE (3.75, 7.50, 15.00, 22.50, and 30.00mM). After 3 hours, D-dimer (DD) levels and WB clot weights were measured for each concentration. Thromboelastography (TEG) parameters were recorded following CAPE incubation, and fibrin morphology was examined under a confocal microscope. Results. Overall, mean DD (

Item Type:	Article
Subjects:	B Philosophy. Psychology. Religion > BD Speculative Philosophy > BD240-260 Methodology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	22 Feb 2018 07:07
Last Modified:	22 Feb 2018 07:07
URI:	http://eprints.usm.my/id/eprint/39119

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