Islam, Md. Asiful and Alam, Fahmida and Solayman, Md. Solayman and Khalil, Md. Ibrahim and Kamal, Mohammad Amjad and Siew, Hua Gan
(2016)
Dietary Phytochemicals: Natural Swords Combating
Inflammation and Oxidation-Mediated Degenerative Diseases.
Oxidative Medicine and Cellular Longevity, 2016 (513743).
pp. 1-25.
ISSN 1942-0900
Abstract
Cumulatively, degenerative disease is one of themost fatal groups of diseases, and it contributes to themortality and poor quality of
life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic
causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellitus (DM), and cardiovascular disease (CVD).
Although a number of synthetic medications are used to treat these diseases, none of the current regimens are completely safe.
Phytochemicals (polyphenols, carotenoids, anthocyanins, alkaloids, glycosides, saponins, and terpenes) from natural products
such as dietary fruits, vegetables, and spices are potential sources of alternative medications to attenuate the oxidative stress and
inflammation associated with degenerative diseases. Based on in vitro, in vivo, and clinical trials, some of these active compounds
have shown good promise for development into novel agents for treating RA, DM, and CVD by targeting oxidative stress and
inflammation. In this review, phytochemicals from natural products with the potential of ameliorating degenerative disease
involving the bone, metabolism, and the heart are described.
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