Abu Backer, Farveen Marican and Nik Mustapha, Nik Raihan and Othman, Nor Hayati
(2011)
Clinicopathological Comparison of Adenocarcinoma of Cervix
and Endometrium Using Cell CycleMarkers: P16ink4a, P21waf1,
and p27Kip1 on 132 Cancers.
Infectious Diseases in Obstetrics and Gynecology, 2011 (857851).
pp. 1-6.
ISSN 1064-7449
Abstract
Objective. We studied the clinicopathological parameters of adenocarcinoma arising from endocervix (ECA) and from
endometrium (EMA) based on the expression of P16ink4a, P21waf1, and p27Kip1 proteins. Study Design. Immunohistochemistry
was done on sections of confirmed ECA and EMA from hysterectomy specimens which have had no prior chemotherapy/
radiotherapy. Results. There were 40 ECAs and 92 EMAs. The mean age of ECA was 49.82 (SD 10.29); the youngest was
30 years old and the oldest 75 years old. The mean age of EMA was 54.45 (SD 10.92); the youngest was 30 years old and the oldest
was 82 years old. For ECA, the size of the tumour is significantly associated with age and with depth of infiltration. FIGO stage
is associated with histological grade. p21WAF1 expression is significantly associated with infiltration of the corpus and lymph
node metastasis. p27Kip1 expression is significantly associated with lymph node invasion. The presence of lymph node metastasis
is strongly associated when p16INK4a and p27Kip1 expressions are analyzed in combination. For EMA, p16INK4a expression is
associated with histologic grade. Conclusion. Our study shows that we could use these cell cycle markers as predictors for more
aggressive subsets of adenocarcinoma of the cervix and endometrium.
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