BoneMicro-CT Assessments in an Orchidectomised RatModel Supplemented with Eurycoma longifolia

Ramli, Rosmaliza and Khamis, Mohd Fadhli and Shuid, Ahmad Nazrun (2012) BoneMicro-CT Assessments in an Orchidectomised RatModel Supplemented with Eurycoma longifolia. Evidence-Based Complementary and Alternative Medicine, 2012 (501858). pp. 1-9. ISSN 1741-427X

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Abstract

Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old) Sprague Dawley rats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7mg/rat testosterone enanthate (TEN) and orchidectomised + Eurycoma longifolia 30 mg/kg (EL30), orchidectomised + Eurycoma longifolia 60 mg/kg (EL60), orchidectomised + Eurycoma longifolia 90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.

Item Type: Article
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Zoom Profil Pakar (Expert Profile) > Mohd Fadhli Khamis (Dental Sciences)
Depositing User: Mr Noorazilan Noordin
Date Deposited: 17 Jan 2018 05:00
Last Modified: 17 Jan 2018 05:00
URI: http://eprints.usm.my/id/eprint/38407

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