Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats

Yusoff, Nor Adlin and Ahmad, Mariam and Al-Hindi, Bassel and Widyawati, Tri and Mun, Fei Yam and Mahmud, Roziahanim and Abdul Razak, Khairul Niza and Asmawi, Mohd Zaini (2015) Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats. Nutrients, 7 (8). pp. 7012-7026. ISSN 2072-6643

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Abstract

Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV) has been used as a folklore medicine among the Malay community to treat diabetes. Early work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect. Thus, this study is conducted to evaluate the effect of AE on postprandial hyperglycemia in an attempt to understand its mechanism of antidiabetic action. AE were tested via in vitro intestinal glucose absorption, in vivo carbohydrate tolerance tests and spectrophotometric enzyme inhibition assays. One mg/mL of AE showed a comparable outcome to the use of phloridzin (1 mM) in vitro as it delayed glucose absorption through isolated rat jejunum more effectively than acarbose (1 mg/mL). Further in vivo confirmatory tests showed AE (500 mg/kg) to cause a significant suppression in postprandial hyperglycemia 30 min following respective glucose (2 g/kg), sucrose (4 g/kg) and starch (3 g/kg) loadings in normal rats, compared to the control group. Conversely, in spectrophotometric enzymatic assays, AE showed rather a weak inhibitory activity against both �-glucosidase and �-amylase when compared with acarbose. The findings suggested that NPV exerts its anti-diabetic effect by delaying carbohydrate absorption from the small intestine through selective inhibition of intestinal glucose transporters, therefore suppressing postprandial hyperglycemia.

Item Type:	Article
Subjects:	R Medicine > RK Dentistry > RK1-715 Dentistry R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article Pusat Pengajian Sains Farmasi (School of Pharmacy) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	12 Jan 2018 08:26
Last Modified:	12 Jan 2018 08:26
URI:	http://eprints.usm.my/id/eprint/38360

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