Aptamer Technology: Adjunct Therapy for Malaria

Nik Kamarudin, Nik Abdul Aziz and Mohammed, Nurul Adila and Mustaffa, Khairul Mohd Fadzli (2016) Aptamer Technology: Adjunct Therapy for Malaria. Biomedicines, 5 (1). pp. 1-14. ISSN 2227-9059

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Abstract

Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as non-immune individuals. The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of IEs, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review, we discuss how the aptamer technology could be applied in the development of a new adjunct therapy for current malaria treatment.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM) > Article Zoom Profil Pakar (Expert Profile) > Khairul Mohd Fadzli Mustaffa (Institute For Research In Molecular Medicine (Health Campus))
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	12 Jan 2018 04:04
Last Modified:	08 May 2019 02:21
URI:	http://eprints.usm.my/id/eprint/38358

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