Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats

Ali, Md. Yousuf and Paul, Sudip and Tanvir, E. M. and Hossen, Md. Sakib and Rumpa, Nur-E Noushin and Saha, Moumoni and Bhoumik, Nikhil Chandra and Islam, Md. Aminul and Hossain, Md. Sabir and Alam, Nadia and Hua Gan, Siew and Khalil, Md. Ibrahim (2017) Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats. Evidence-Based Complementary and Alternative Medicine, 2017 (297976). pp. 1-15. ISSN 1741-427X

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Abstract

The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated.The acute antihyperglycemic effect of different doses of GP was studied in normalmaleWistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of maleWistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals. There were increased lipid peroxidation and reduced levels of cellular antioxidant enzymes in different tissues of diabetic rats. However, oral administration of GP extracts, especially the highest dose (1000mg/kg), significantly ameliorated hyperglycemia (42%); elevated insulin levels (165%); decreased HbA1c (29.4%); restored lipid levels (reduction in TG by 25%, TC by 15%, and LDL-C by 75% and increase in HDL-C by 4%), liver and renal function markers, and lipid peroxidation (reduction by 52% in the liver, 39% in the kidney, 44% in the heart, and 46% in the pancreas); and stimulated tissue antioxidant enzymes to near normalcy. Overall, the findings suggest that GP fruit is effective against hyperglycemia and could be used in the treatment of diabetes and its complications and other oxidative stress-mediated pathological conditions.

Item Type:	Article
Additional Information:	Article ID 2979760
Subjects:	R Medicine > R Medicine (General)
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	10 Jan 2018 08:32
Last Modified:	10 Jan 2018 08:32
URI:	http://eprints.usm.my/id/eprint/38332

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