Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats

Kwan, Yuet Ping and Ibrahim, Darah and Yeng, Chen and Subramaniam, Sreeramanan and Sreenivasan, Sasidharan (2013) Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International, 2013 (182064). pp. 1-14. ISSN 2314-6133

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Abstract

Despite Euphorbia hirta L. ethnomedicinal benefits, very few studies have described the potential toxicity.The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E. hirta.The acute and subchronic oral toxicity of E. hirta was evaluated in Sprague Dawley rats. The extract at a single dose of 5000mg/kg did not produce treatment related signs of toxicity or mortality in any of the animals tested during the 14-day observation period. Therefore, the LD 50 of this plant was estimated to be more than 5000mg/kg. In the repeated dose 90-day oral toxicity study, the administration of 50mg/kg, 250mg/kg, and 1000mg/kg/day of E. hirta extract per body weight revealed no significant difference (

Item Type:	Article
Subjects:	Q Science > QH Natural history > QH1 Natural history (General - Including nature conservation, geographical distribution) R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM) > Article Pusat Pengajian Sains Kajihayat (School of Biological Sciences) > Article Zoom Profil Pakar (Expert Profile) > Sasidharan A/L Sreenivasan (Institute for Research In Molecular Medicine) Zoom Profil Pakar (Expert Profile) > Sreeramanan A/L Subramaniam (Biological Sciences) Zoom Profil Pakar (Expert Profile) > Darah Ibrahim (Biological Sciences)
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	05 Jan 2018 01:40
Last Modified:	05 Jan 2018 01:40
URI:	http://eprints.usm.my/id/eprint/38244

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