Nohl, L.M. and Rus Anidah, R.A. and Thiyagara, N. and Abd Hamid, Intan Juliana and Hashim, I. and Latif, A.H. (2012) CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. Journal of Clinical Immunology, 32 (1 Sup.). p. 289. ISSN 0271-9142
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Abstract
Cases of CD 19 deficiency from South East Asia has rarely been reported. A, 1l yr Malay boy was referred with recurrent infections with 2 episodes of'chickenpox at age 2 years. He had repeated episodes of pneumoniae and bronchiectasis by age 6 years. Physical examination revealed gross clubbing with crepitations at both lung bases. IV lg administration was instituted with clinical improvementlaboratory data: Serum Ig (g/l )IgG 8.37[n 4.95- 16.56 ], IgA 0.92[n 0.30-2.35 7, lgM 0.21 [0.32-1.4}]Lymphocyte subset (age 1l) CD19 Q o , CD20 11.26% (12-22)CD3 83.64% (n 66-76) ,CD4 36.25 ( 33-41),CD8 41.55 (27- 35), CDl6+56 I1.6 %. (9-16),Specific antibody response to polysaccharide antigen was impaired ; whileNBT , lymphocyte proliferation to (PHA ) were normal, Btk protein 18% (control 87.8 %). Our finding conforms with a diagnosis of CD19 deficiency with selective IgM deficiency and partial defective Btk protein expression.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article Zoom Profil Pakar (Expert Profile) > Intan Juliana Abd Hamid (Advanced Medical & Dental Institute) |
| Depositing User: | Administrator Automasi |
| Date Deposited: | 14 Nov 2017 09:08 |
| Last Modified: | 14 Nov 2017 09:08 |
| URI: | http://eprints.usm.my/id/eprint/37398 |
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