Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study

Abd Kadir, Erazuliana and Sulaiman, Siti Amrah and Yahya, Nurul Khaiza and Othman, Nor Hayati (2013) Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study. Asian Pacific Journal of Cancer Prevention, 14 (4). pp. 2249-2254. ISSN 1513-7368

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Abstract

The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1 served as a Control while Groups 2, 3 and 4 received 0.2, 1.0 or 2.0 g/kg bodyweight/day of TH, respectively, for 150 days. Results showed that breast cancers in the TH-treated groups had slower size increment and smaller mean tumor size (≤2cm3 ) compared to Controls (≤8cm3 ). The number of cancers developing in TH-treated groups was also significantly fewer (P<0.05). Histological grading showed majority of TH–treated group cancers to be of grade 1 and 2 compared to grade 3 in controls. There was an increasing trend of apoptotic index (AI) seen in TH-treated groups with increasing dosage of Tualang Honey, however, the mean AI values of all TH-treated groups were not significantly different from the Control value (p>0.05). In conclusion, Tualang Honey exerted positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study

Item Type:	Article
Subjects:	R Medicine > RJ Pediatrics > RJ370-550 Diseases of children and adolescents
Divisions:	Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article Zoom Profil Pakar (Expert Profile) > Erazuliana Abd Kadir (Advanced Medical & Dental Institute)
Depositing User:	Administrator Automasi
Date Deposited:	02 Nov 2017 09:40
Last Modified:	02 Nov 2017 09:40
URI:	http://eprints.usm.my/id/eprint/37322

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