Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Suk, Peng Tang and Nainamohamed Salam, Sirajudeen Kuttulebbai and Jaafar, Hasnan and Siew, Hua Gan and Muzaimi, Mustapha and Sulaiman, Siti Amrah (2017) Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity, 2017 (460578). pp. 1-12. ISSN 1942-0900

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Abstract

Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10mg/kg/week) once per week for four consecutive weeks. After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ (

Item Type:	Article
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	30 Oct 2017 09:51
Last Modified:	30 Oct 2017 09:51
URI:	http://eprints.usm.my/id/eprint/37275

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