Zakaria, Norashikin and Satar, Nazilah Abdul and Halim, Noor Hanis Abu and Ngalim, Siti Hawa and Yusoff, Narazah Mohd and Lin, Juntang and Yahaya, Badrul Hisham
(2017)
Targeting Lung Cancer Stem Cells: Research and Clinical Impacts.
Frontiers in Oncology, 7 (80).
pp. 1-10.
ISSN 2234-943X
Abstract
Lung cancer is the most common cancer worldwide, accounting for 1.8 million new
cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one
of two types of lung cancer, accounts for 85–90% of all lung cancers. Despite advances
in therapy, lung cancer still remains a leading cause of death. Cancer relapse and dissemination
after treatment indicates the existence of a niche of cancer cells that are not
fully eradicated by current therapies. These chemoresistant populations of cancer cells
are called cancer stem cells (CSCs) because they possess the self-renewal and differentiation
capabilities similar to those of normal stem cells. Targeting the niche of CSCs in
combination with chemotherapy might provide a promising strategy to eradicate these
cells. Thus, understanding the characteristics of CSCs has become a focus of studies
of NSCLC therapies.
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