Fu, Xianjun and Song, Xuxia and Li, Xuebo and Keng Wong, Keng Wong and Li, Jiaoyang and Zhang, Fengcong and Wang, Changyun and Wang, Zhenguo
(2017)
Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity.
Evidence-Based Complementary and Alternative Medicine, 2017 (436571).
pp. 1-10.
ISSN 1741-427X
Abstract
Traditional Chinese Marine Medicine (TCMM) represents one of the medicinal resources for research and development of novel
anticancer drugs. In this study, to investigate the presence of anticancer activity (AA) displayed by cold or hot nature of TCMM,
we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated
from 1,091 species of marine organisms) via association rules mining and phylogenetic tree analysis. The screened association
rules were collected from three taxonomy groups: (1) Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae
family, and Sargassum genus; (2) Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family;
(3) Holothuroidea class, Aspidochirotida order, and Holothuria genus. Our analyses showed that TCMMs with closer taxonomic
relationship weremore likely to possess anticancer bioactivity.We found that the cluster pattern ofmarine organisms with reported
AA tended to cluster with cold nature TCMMs. Moreover, TCMMs with salty-cold nature demonstrated properties for softening
hard mass and removing stasis to treat cancers, and species withinMetazoa orViridiplantae kingdomof cold natureweremore likely
to contain AA properties.We propose that TCMMs from these marine groups may enable focused bioprospecting for discovery of
novel anticancer drugs derived from marine bioresources.
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