Yean, Chun Loh and Chu, Shan Tan and Yung, Sing Ch’ng and Ahmad, Mariam and Asmawi, Mohd Zaini and Mun, Fei Yam
(2016)
Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways.
Molecules, 21 (4).
pp. 1-34.
ISSN 1420-3049
Abstract
This paper is a review on the types of antagonists and the signaling mechanism pathways
that have been used to determine the mechanisms of action employed for vasodilation by test
compounds. Thus, we exhaustively reviewed and analyzed reports related to this topic published in
PubMed between the years of 2010 till 2015. The aim of this paperis to suggest the most appropriate
type of antagonists that correspond to receptors that would be involved during the mechanistic
studies, as well as the latest signaling pathways trends that are being studied in order to determine
the route(s) that atest compound employs for inducing vasodilation. The methods to perform
the mechanism studies were included. Fundamentally, the affinity, specificity and selectivity of
the antagonists to their receptors or enzymes were clearly elaborated as well as the solubility and
reversibility. All the signaling pathways on the mechanisms of action involved in the vascular tone
regulation have been well described in previous review articles. However, the most appropriate
antagonists that should be utilized have never been suggested and elaborated before, hence the
reason for this review.
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