Zainol Abidin, Azrul Syafiq and A. Rahim, Ruslinda and Md Arshad, Mohd Khairuddin and Mohd Faudzi, Fatin Nabilah and Chun, Hong Voon and Tang, Thean Hock and Marimuthu, Citartan
(2017)
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC).
Sensors, 17 (1180).
pp. 1-13.
ISSN 1424-8220
Abstract
Anxiety is a psychological problem that often emerges during the normal course of human
life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire.
However, these approaches have limitations, as the data might lack reliability and consistency upon
application to the same population over time. Furthermore, there might be varying understanding
and interpretations of the particular question by the participant, which necessitating the approach of
using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to
stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response,
and suppresses the digestive and the reproductive systems. We have taken the endeavour to review
the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care
diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged.
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