Abdullah, Abu Dzarr Ganesh
(2002)
Validation of international prognostic index for non-hodgkin's lymphoma in northeast Peninsular Malaysian Malays.
Masters thesis, Universiti Sains Malaysia.
Abstract
Indeks Prognosis Antarabangsa {IPI) telah diketengahkan untuk menstratumkan risiko
pesakit limfoma bukan Hodgkin (NHL) dan mengenalpasti subset pesakit berisiko tinggi
yang mungkin tidak dapat bertindakbalas terhadap kemoterapi dengan memuaskan. IPI
telah dibentuk berlandaskan model populasi pesakit berbangsa barat. Kami telah
menlaksanakan suatu kajian longitudinal melibatkan pesakit NHL aggresif yang
menerima rawatan di Hospital USM dari I haribulan J anuari 1990 ke 31 haribulan
Disember 2000. Kajian ini hanya melibatkan pesakit berbangsa Melayu. Ini bertujuan
untuk menguji kesesuaian penggunaan IPI ke atas etnik tersebut. Ciri-ciri klinikal
sepertimana yang telah diuji dalam model IPI yang asal, telah diuji ke atas kohort kami.
Pencapaian pesakit dari segi kadar respons sempurna (complete response rate : CR),
kadar kemandirian keseluruhan (overall survival rate: OS) dan kadar kemandirian bebas
penyakit (disease free survival rate: DFS) bagi setiap faktor eli atas telah eli olah. Pada
masa yang sama data-data yang diperolehi telah digunakan untuk membentuk profit
penyakit NHL dalam populasi kami.
International prognostic index (IPI) was introduced to risk stratify non-Hodgkin
lymphoma (NHL) patients and to identify high-risk patient who might not respond
favorably to standard chemotherapy. IPI was modeled from a Caucasian based patient
population. We undertook a single center, observational longitudinal study involving all
available patients with aggressive NHL who had received treatment from Hospital USM
between 1st Jan 1990 and 31st Dec 2000. We confined our study to adult Malay patients
to test the applicability of IPI in this racial group. Individual presenting clinical features
was categorized as in the IPI study, and the patients' outcome in terms of complete
response (CR), overall survival (OS) and disease free survival (DFS) rates for each of the
above features were determined. At the same time the available data was used to
characterize NHL disease profile in our patient population.
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