Abdul Hadi, Muhammad Fahmi Rizal (2025) Development Of A Monte Carlo-Based Treatment Planning System For Personalized Dosimetry In Yttrium-90 Hepatic Radioembolization. PhD thesis, Universiti Sains Malaysia.
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Abstract
Yttrium-90 (90Y) hepatic radioembolization is a targeted therapy for liver cancer that depends on accurate dosimetry for both treatment efficacy and safety. Conventional dose estimation using the Partition Model (PM) often overlooks patient-specific anatomy and radiation crossfire effects, leading to potential inaccuracies. This study presents a cross-platform treatment planning system (TPS) integrating Monte Carlo (MC) simulations to improve personalised dosimetric evaluation. Pre-treatment CT and 99mTc-MAA SPECT images from patients at University of Malaya Medical Centre were segmented using 3D Slicer to define volumes of interest (VOIs), including lungs, normal liver, and tumour.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | Q Science > QC Physics > QC1-999 Physics |
| Divisions: | Pusat Pengajian Sains Fizik (School of Physics) > Thesis |
| Depositing User: | Mr Aizat Asmawi Abdul Rahim |
| Date Deposited: | 23 Sep 2026 02:25 |
| Last Modified: | 23 Sep 2026 02:25 |
| URI: | http://eprints.usm.my/id/eprint/65014 |
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