Shunmugham, Thavan Raj (2025) Production Of Postbiotic By Lactic Acid Bacteria Through Fermentation Process As Potential Antidiabetic Agent. Masters thesis, Perpustakaan Hamzah Sendut.
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Abstract
In response to the notable adverse health effects associated with the use of chemically synthesized antidiabetic drugs for individuals with diabetes, a comprehensive investigation was undertaken to explore the potential of postbiotic compounds produced by lactic acid bacteria (lab) as novel antidiabetic agents, with a particular focus on their inhibitory effects compared to acarbose. Seven lab strains were cultured to obtain supernatants and heat-killed cell (hkc) which was exposed to 80℃, which were subsequently evaluated for their inhibitory activities against α-amylase and α-glucosidase enzymes. The supernatant from lactobacillus acidophilus tp7 culture exhibited the most significant α-amylase inhibitory activity, with a percentage of 79.01 ± 1.35%, while hkc of lactococcus lactis c22 displayed an inhibition percentage of 58.17 ± 3.08%. For α-glucosidase inhibition, limosilactobacillus reuteri bm5 showed the highest inhibition percentage in both the supernatant and hkc, with percentages of 68.08 ± 0.03% and 67.78 ± 1.18%, respectively. Further fractionation of exopolysaccharide (eps), small molecules, and proteins was carried out, revealing that the crude eps extracted from l. Acidophilus’s supernatant exhibited the most remarkable inhibitory effects, with 95.90% inhibition in the α-amylase test and 75.51% inhibition in the α-glucosidase test, surpassing the other fractionated components
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | T Technology > T Technology (General) > T1-995 Technology(General) |
| Divisions: | Pusat Pengajian Teknologi Industri (School of Industrial Technology) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 07 May 2026 02:19 |
| Last Modified: | 07 May 2026 02:19 |
| URI: | http://eprints.usm.my/id/eprint/64099 |
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