Ang, Xin Yee
(2022)
Effects Of Lactobacillus Spp. Against Vaginal Candidiasis In Pregnant Women.
Masters thesis, Perpustakaan Hamzah Sendut.
Abstract
This study aimed to investigate the effects of lactobacilli probiotics in
preventing the recurrences of vulvovaginal candidiasis (VVC) in 78 pregnant women
with VVC (probiotic, n = 39; placebo, n = 39) and the potential benefits on quality of
life. The lactobacilli probiotic (SynForU-HerCare; two capsules/day of 9.5 log
CFU/capsule) or placebo was administered for 8-weeks in a randomized, double-blind,
and placebo-controlled study. Subjects were assessed for vaginal and gut health
conditions at week-0, 4, and 8 via questionnaires and analyzed vaginal microbiota and
inflammatory changes. The vulvovaginal symptom questionnaire covered vulvovaginal
symptoms and quality of life. Probiotic group was exhibited the reduction of irritation
(P=0.023) and discharge (P=0.011) starting week-4 and continued after week-8 (P<0.05)
as compared to the placebo. Probiotic group was exhibited the reduction of concern
about symptoms after week-4 (P=0.010) and continued after week-8 (P=0.001),
accompanied by reduced impairment of daily activities (P=0.012) and continued after
week-8 (P=0.026). Probiotic group was exhibited the reduction of recurrences of both
emotional and social stress compared to the placebo at both week-4 and week-8
(P<0.05). Probiotic group showed higher defecation times per week at week-4 (P=0.010)
and week-8 (P=0.001) compared to the placebo group.
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