Rahimah, Zakaria
(2012)
The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
Alterations in the levels of oxidative stress and haemostatic markers have
been proposed as one of the mechanisms for obesity-related cardiovascular
disease. This study aims to evaluate the effect of 12-week behavioral lifestyle
modification program on the oxidative stress levels in obese subjects. This is
an interventional prospective study conducted from April 2009 through
December 2010. Thirty four obese adult recruited from the Obesity Clinic,
Hospital Universiti Sains Malaysia participated in the 12-week behavioral
lifestyle modification program consisting of diet and exercise interventions.
Body weight, BMI and body fat were significantly reduced after 12-week
interventions. Plasma GPx activity and 4-HNE concentration increased
significantly after 12-week interventions. Other enzymatic antioxidant activities
such as CAT and SOD increased, and GSH:GSSG ratio reduced but the
changes were not statistically significant. Plasma fibrinogen, factor VII, TAFI,
t-PA and PAI-1 levels were significantly decreased and plasma Heparin
Cofactor II level was significantly increased after 12-week intervention. In
conclusion, diet and exercise interventions reduce cardiovascular risk factors
by reducing body fat, increasing enzymatic antioxidant defense and
beneficially altering the levels of haemostatic markers in obese adults.
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