Noraizal, Che Hamzah
(2012)
Anti-hepatitis a virus seroprev alence
among chronic viral hepatitis B and C
HUSM and its association with Cyp3a4*18
polymorhism.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
CYP3A4 is the major cytochrome in humans which shows reduced activity in chronic
liver disease as well as in hepatic cirrhosis. The detection of this polymorphism may give an indication on
the prognosis of patients having chronic viral hepatitis with superimposed hepatitis A infection. The aim of
this study is to correlate the seroprevalence of anti-HAV antibodies in chronic liver disease patients having
CYP3A4*18 polymorphisms. Methodology: This is a prospective study where patients' (n=ll9) blood was
tested for anti-HAVlgG and CYP3A4* 18 polymorphism. Results: The overall anti-HAV seroprevalence was
88.2%. The etiology of CLD was hepatitis B in 96 patients (80.7%) and hepatitis C in 23 patients (19.3%).
There was a significant increase in the age of the prevalence of this disease after 30 years of age (p=0.008).
CYP3A4* 18 polymorphism was detected in 3 (2.5%) of the patients with chronic liver disease. However, there
was no significant association between CP3A4*18 mutation and anti-HAV serology. Conclusions: Age was
the most important factor in determining anti-HAV positivity. It is concluded that CYP3A4*18 genetic polymorphism
does not play a main role in influencing the seroprevalence of anti-hepatitis A among chronic viral
hepatitis B and C liver disease patients.
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