Rosline, Hassan
(2013)
Determination of ph of platelet
concentrates and its relations with
febrile non-hemolytic transfusion
reactions.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
Platelet transfusion is associated with numerous adverse reactions and the most common one is
febrile non-haemolytic transfusion reaction (FNHTR). Although it is not a life threatening
condition, the clinical symptoms could lead to discomfort to the patients as well as utilizing the
nursing and laboratory resources. Platelet concentrates are stored at 22•c which can lead to
increased lactate production as a result of glycolysis and falling in pH. Moreover the presence of
leucocytes and bacterial contamination in the platelets concentrate lead to a competition for the
availability of oxygen which too, will result in a rapid fall in the pH. This study was done to
determine the relationship between pH of the platelet concentrates and febrile non haemolytic
transfusion reaction ( FNHTR) and to correlate the pH with the white blood cell & platelet
count presence in the platelet concentrates. Hundred and fifty samples of platelet concentrates
were included in this study . Only 4 episodes of febrile reactions were detected in I 04 episodes
of transfusion. The pH of the platelet concentrates was reduced throughout the day but was still
maintained within the guideline recommendations. There was a significant correlation between
pH and platelet count but not with the WBC count. There was no bacterial contamination
detected in all the units studied. As a conclusion, the incidence of FNHTR is low among patients
receiving platelet transfusion in this study and did not appear to be associated with pH. Based on
the mean pH value of the platelet concentrates were well maintained within the usual 5 days,
thus an extension of platelet storage time is recommended.
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