Mohamed, Mahaneem
(2010)
A preliminary study: effect of local honey on
spermatogenesis in rats.
Other.
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia.
Abstract
The aim of this study was 10 evaluate the effect of different doses of Malaysian honey on male reproductive
parameters in adult rats. Thirty-two healthy adult male Sprague-Dawley rats were randomly divided into 4
groups (8 rats per group). Group 1 (control group) was given 0.5 ml of distilled water. Groups 2, 3 and 4 were
given 0.2, 1.2 and 2.4 g kg·' body weight of honey, respectively. The rats were treated orally by gavage once
daily for 4 weeks. Honey did not significantlr alter body and male reproductive organs weights. The rats in
Group 3 which received honey at 1.2 g kg· had significantly higher epididymal sperm count than those in
Groups 1, 2 and 4. No significant differences were found for the percentage of abnormal sperm, elongated
spermatid count, reproductive hormonal levels as well as the histology of the testis among the groups. In
conclusion, Malaysian honey at a dose of 1.2 g kg·' daily significantly increased epididymal sperm count without
affecting spermatid count and reproductive hormones. These findings might suggest that oral administration of
honey at this dose for 4 weeks may enhance spermiogenesis in adult rats .
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