Daud, Kamaliah Mohd
(2010)
The effects of adjuvant honey
therapy on disease activity,
lymphocyte function and
lymphocyte subsets in patients with systemic lupus erythematosus (SLE).
Other.
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia.
Abstract
Objectives: To compare the effects of adjuvant tualang honey therapy versus conventional therapy alone
on disease activity, lymphocyte functions and lymphocyte subsets in SLE patients.
Methodology: Sixty SLE patients from Hospital Universiti Sains Malaysia were randomized into two equal
groups, group 1 receiving conventional treatment with low dose steroid and cyclophosphamide or
azathioprim, group 2 receiving same treatment in addition to tualang honey 20 gm twice a day. Disease
activity was measured in all patients every 3 months by SLEDAI score, the function of T lymphocyte was
determined at baseline and after 6 months by measuring the expression of 3 lymphocyte activation
markers (HLADR, CD45RO and CD25). Enumeration of lymphocyte subsets (CD3, CD4, CDB, CD19, and
CD16/56) was done at baseline and after 6 months.
Results: The SLEDAI score was significantly decreased in honey group compared to non honey group
after 3 and 6 months of follow up. There was a significant decrease in the expression of CD8CD45RO and
CD8CD25 in honey group.There was a significant increase in CD3 and CD16/56 percentage in honey
group after 6 months follow up.
Conclusion: The use of honey therapy as adjuvant to conventional treatment in patients with SLE was
found to be useful in suppressing disease activity and enhancing lymphocyte function and lymphocyte
subsets.
Actions (login required)
 |
View Item |
