Mahmood, Nik Mohd Zaki Nik and Ghaffar, Nor Aliza and Halim, Ahmad Sukari and Halim, Abdul
(2011)
Large arterial compliance and
mirovascular function in women with
gestational diabetes.
Large .arterial compliance and mirovascular function in women with gestational diabetes.
Abstract
Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to
assess microvascular reactivity. This study aims to compare PORH response among pregnant
hypercholesterolaemic patients with age and gestational age-matched controls.
Methods: This cross sectional study involved 17 hypercholesterolaemic, pregnant women
and 20 pregnant controls entering their early third trimester. Laser Doppler fluximetry (LDF) was
used to measure skin perfusion. The process of PORH was performed by occluding the upper arm
with an occlusion cuff at 200 mmHg for 3 minutes. Sld.n perfusion was recorded before, during, and
after occlusion release. Baseline perfusiOn, time to achieve peak perfusion (Tp), peak perfusion after
occJusion release (PORHpeak), and maximum change in perfusion due to occlusion (PORHma) were
recorded. .
Results: Serum total cholesterol (TC) was significantly different (P < o.oo1) between the 2
groups: 7.25 (SEM 0.18) mmoi/L for hypercholesterolaemic women and 5.54 (SEM 0.15) mmoi/L for
the control group. There were no significant differences in their baseline, PORHpe~~k' and PORH ... o.x'
However, Tp in the hypercholesterolaemic group was significantly increased (P = 0.024) compared
"'ith the controls at 14.9 (SEM o.6) seconds and 13.1 (SEM o.s) seconds, respectively.
Conclusion: Pregnant hypercholesterolaemic patients showed an abnormal
microvascular reactivity response. Tp with ischemia was significantly increased compared with
nonnocholesterolaemic controls.
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