Ting Lim, Hui
(2020)
Effects Of A Lactobacilli Probiotic
On Survival And Mobility Of
Female Drosophila Melanogaster
With Alzheimer’s Disease.
Project Report.
Pusat Pengajian Teknologi Industri.
(Submitted)
Abstract
Alzheimer's disease (AD), as the most prevalent form of aging-associated
neurodegenerative disease, progressed in an irreversible manner while approaching
epidemic proportions with no cure or preventative therapy yet available. The probiotic
strain Lactobacillus fermentum DR9 has been reported for exhibiting anti-aging effects
on lifespan and muscle in senescence-induced rats, with AD-reversal potential by
alleviating neurodegeneration in the eye of AD-induced Drosophila. Using an
inducible Drosophila AD model by human Aβ42 expression with UAS/GAL4 system,
the study was carried out to evaluate the effects of probiotic administration on the
survival and mobility of female Drosophila melanogaster with AD. Evaluated by
survival assay, the administration of L. fermentum DR9 for 24 days improved survival
by increasing the survival percentage of female D. melanogaster AD model, as
compared to the untreated control.
Actions (login required)
 |
View Item |
