Razak, Noor Hayati Abdul and Samsudin, Ab. Rani and Omar, Nor Shamsuria
(2004)
In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material.
In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material.
(Submitted)
Abstract
The objective of the study is to evaluate the osteoconductive, osteoinductive and
biocompatibility properties of a locally produced dense hydroxyapatite (HA) as
bone replacement material in mandibles. The study was carried out on 8 New
Zealand White rabbits. Defects were created in the mandible of a rabbit model
whereby the right side was implanted with HA while the left side was left empty to
act as a control. The dense HA blocks with the pore size of < 5J.1m promotes bone
ingrowth as early as 4 weeks when viewed by the topographic method. Both the
implant and control sites were evaluated clinically and histologically at 4, 12, 20, 22
weeks interval. Enhancement of osteoconduction was evident by the presence of
abundant capillaries, perivascular tissue and osteoprogenitor cells of the host
accounting for the new bone filling the gap and remodelling taking place. This
study demonstrated that the dense HA exhibits excellent biocompatibility as noted
by the complete absence of reactive cells. HA also promotes osteoconduction. It
appears that this locally manufactured HA has the potential to be a valuable
replacement material for maxillofacial reconstructive surgery and orthopaedic
surgery.
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