Synthesis And Characterization Of pH-Sensitive Polyelectrolyte Nanogels For Oral Delivery Of Bovine Serum Albumin And Insulin As Model Proteins

Mudassir, Jahanzeb (2018) Synthesis And Characterization Of pH-Sensitive Polyelectrolyte Nanogels For Oral Delivery Of Bovine Serum Albumin And Insulin As Model Proteins. PhD thesis, Universiti Sains Malaysia.

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Abstract

Peptide and protein are administered parentrally owing to their instability and insufficient bioavailability through oral route. Parenteral administration is associated with poor patient compliance due to pain and discomfort by multiple injections. Oral administration can be beneficial to improve patient compliance and physiologic response to peptide and protein (e.g. insulin). The aim of the present study was to synthesize pH sensitive polyelectrolyte methyl methacrylate/itaconic acid (MMA/IA) nanogels to be used as a carrier for oral delivery of model proteins (BSA and insulin).

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 14 Mar 2019 02:44
Last Modified: 12 Apr 2019 05:24
URI: http://eprints.usm.my/id/eprint/43653

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