Phosphorylation And Regulation Of Human Choline Kinase Beta By Protein Kinase A

Chang , Ching Ching (2015) Phosphorylation And Regulation Of Human Choline Kinase Beta By Protein Kinase A. PhD thesis, USM.

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Abstract

Kolina kinase (CK) adalah enzim pertama yang terlibat dalam laluan CDP-kolina untuk proses biosintesis fosfatidilkolina yang merupakan komponen utama fosfolipid membran. CK terdiri daripada tiga isoform iaitu CKα1, CKα2 dan CKβ. Pengawalaturan enzim ini adalah penting dari segi fisiologi. Perubahan metabolik CKα telah dikaitkan dengan pembentukan tumor, manakala mutasi atau pemadaman gen chkβ boleh menyebabkan distrofi otot. Choline kinase (CK) is the first enzyme involved in CDP-choline pathway for the biosynthesis of phosphatidylcholine, the major component of membrane phospholipid. CK exists as three isoforms, which are CKα1, CKα2 and CKβ. The regulation of these enzymes is physiologically important. Metabolic alterations of CKα are associated with tumorigenesis, while mutation or deletion of chkβ gene leads to the development of muscular dystrophy.

Item Type:	Thesis (PhD)
Subjects:	R Medicine > R Medicine (General) > R5-130.5 General works
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Thesis
Depositing User:	Mr Firdaus Mohamad
Date Deposited:	08 Aug 2018 02:42
Last Modified:	12 Apr 2019 05:25
URI:	http://eprints.usm.my/id/eprint/41256

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