Elucidation of the mechanism involves in norovirus subgenomic RNA (sgRNA) synthesis:A rationale for attenuation in vaccine development.

Yunus, Muhammad Amir (2017) Elucidation of the mechanism involves in norovirus subgenomic RNA (sgRNA) synthesis:A rationale for attenuation in vaccine development. Technical Report. Universiti Sains Malaysia.

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Abstract

Norovirus, ahli datam famili Caliciviridae iaitu virus daripada RNA bebenang tunggal positif telah dikenalpasti menghasilkan spesis RNA subgenomik semasa replikasi aktif virus berkenaan dalam sel yang dijangkiti.Walaubagaimanapun, mekanisma bagi sintesis RNA subgenomik bagi virus ini masih belum dicirikan sepenuhnya. Kaiian yang lepas melibatkan murine norovirus (MNV) telah menemui struktur RNA 'stem-loop' yang konsisten pada bebenang negatif RNA genom virus yang bereplikasi, iaitu pada bahagian yang mengekod enzim 'RNA-dependent RNA polymerase'.

Item Type: Monograph (Technical Report)
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute) > Monograph
Zoom Profil Pakar (Expert Profile) > Dr. Muhammad Amir Yunus (Advanced Medical & Dental Institute)
Depositing User: Mr Erwan Roslan
Date Deposited: 02 Oct 2017 14:53
Last Modified: 21 Nov 2017 10:34
URI: http://eprints.usm.my/id/eprint/36855

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