Quantative analysis of brain white matter using diffusion tensor imaging

Mohd Taib, Nur Hartini (2014) Quantative analysis of brain white matter using diffusion tensor imaging. PhD thesis, Universiti Sains Malaysia.

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    Abstract

    Penyelidikan ini mengenai aplikasi pengimejan tensor difusi (DTI) dalam kajian tentang leukoaraiosis dan jirim putih normal. Empat objektif utama yang telah digariskan dalam kajian ini telah tercapai. Sebuah fantom kepala telah digunakan dan sejumlah 15 subjek normal dan 51 subjek leukoaraiosis telah mengambil bahagian dalam kajian ini. Sejumlah 5128 hirisan telah dianalisis dalam kerja ini. Pengimejan otak telah dijalankan menggunakan sistem pengimejan resonan magnet (MRI) 1.5 Tesla. Keupayaan mendapatkan data DTI dan membina trektografi gentian untuk kajian leukoaraiosis telah dikaji. Hasil yang didapati menunjukkan kebolehan DTI untuk membezakan leukoaraiosis daripada jirim putih normal. Trektografi gentian telah menunjukkan perbezaan struktur yang jelas bagi gentian saraf dalam kawasan jirim putih. Dapat disimpulkan data DTI dan pembinaan trektografi gentian untuk penilaian leukoaraiosis didapati boleh dilaksanakan. This research is concerned with the application of diffusion tensor imaging (DTI) in the study of leukoaraiosis and normal white matter. Four main objectives outlined in the study have been achieved. A head phantom was used and a total of 15 normal subjects and 51 leukoaraiosis subjects participated in the study. A total of 5128 slices were analysed in this work. Brain imaging was performed using 1.5 Tesla MRI system. Feasibility of acquiring DTI data and constructing fiber tracts for leukoaraiosis study was investigated. Results obtained showed capability of DTI to distinguish leukoaraiosis from normal white matter. Fiber tractography exhibited a good structural differentiation of nerve fibers in the white matter region. Acquiring DTI data and constructing fiber tractography for assessment of leukoaraiosis was found to be feasible.

    Item Type: Thesis (PhD)
    Subjects: R Medicine > R Medicine (General) > R5-130.5 General works
    Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences)
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 11 Sep 2017 15:56
    Last Modified: 11 Sep 2017 15:56
    URI: http://eprints.usm.my/id/eprint/36435

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