Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease

R., Zakaria and W. M. H., Wan Yaacob and Z., Othman and I. , Long and A. H. , Ahmad and B. , Al-Rahbi (2017) Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease. Physiological research. ISSN 0862-8408

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    Abstract

    Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD.

    Item Type: Article
    Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
    Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Article
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 26 Jul 2017 09:06
    Last Modified: 26 Jul 2017 09:06
    URI: http://eprints.usm.my/id/eprint/35859

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