Long, Idris and Abd Rashid, Norlinda
(2015)
The Potential Role of Nicotine in the Treatment
of Learning and Memory Impairment after REM
Sleep Deprivation.
Journal of Multidisciplinary Research in Healthcare, 2 (1).
pp. 17-30.
Abstract
Sleep deprivation has become a contributing factor to the world’s
health concerns such as cardiovascular disease, mental illness and inattentiveness
in occupationand decision making. It can also disturb synaptic plasticity that
can lead to learning and memory impairment. Therefore, boosting cholinergic
activity using acetylcholine imitator that can be found in the tobacco plant,
known as nicotine, is essential in reversing the negative influences of sleep loss
in the brain. Thus, studies on the effects of nicotine treatment on molecular
mechanisms and structural changes of hippocampal brain cells are vital in order
to gain more understanding and to overcome the detrimental consequencesof
learning and memory impairment related to sleep divest.
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