THE EFFECTS OF OPEN FIELD EXPOSURE ON THE ANXIETY AND LOCOMOTIVE BEHAVIOR OF ADULT MALE WISTAR RATS IN ELEVATED PLUS MAZE

Kumar, Jaya and Hapidin, Hermizi and Get Bee, Yvonne-Tee and Ismail, Zalina (2016) THE EFFECTS OF OPEN FIELD EXPOSURE ON THE ANXIETY AND LOCOMOTIVE BEHAVIOR OF ADULT MALE WISTAR RATS IN ELEVATED PLUS MAZE. Regenerative Research, 4 (2). pp. 11-14. ISSN 2232-0822

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    Abstract

    Anxiety is a multifaceted emotional disorder which requires multiple research models for effective assessment of the condition. Usually, a large number of animals will be used for a single study which will not be reused in other studies. The use of different groups of animals for different aspects of any study may create inter-subject variations that can confound the observed results. Objective of this study is to investigate the effect of pre-exposure to open field (OF) on the anxiety and locomotor behaviors of male adult Wistar rats in elevated plus maze (EPM). We evaluated the effect of pre-exposure in OF on the anxiety and locomotor behaviors of rats at 3 different time intervals. The control group consisted of rats which underwent single exposure in EPM, and the other three groups consisted of rats which underwent a pre-exposure in OF immediately before the EPM session, 2 days before the EPM session, and a week before the EPM session. Our results show that there was no significant effect of OF pre-exposure on the anxiety and the locomotive behavior of rats in EPM at these 3 different intervals. In conclusions, these tests can be conducted successively with minimum time duration in the gap between these two tests.

    Item Type: Article
    Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
    Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Article
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 21 Jul 2017 15:48
    Last Modified: 21 Jul 2017 15:48
    URI: http://eprints.usm.my/id/eprint/35782

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