α1-Adrenoceptors And At1 Receptors In The Modulation Of Renal Hemodynamics In High Salt And Doca Models Of Hypertensive Rats Treated With Tempol And Losartan

Yen, Pei Pei (2016) α1-Adrenoceptors And At1 Receptors In The Modulation Of Renal Hemodynamics In High Salt And Doca Models Of Hypertensive Rats Treated With Tempol And Losartan. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Hipertensi merupakan penyebab utama morbiditi dan kematian yang berkait rapat dengan kerosakan ginjal. Pengambilan garam lebihan menyumbang kepada pathogenesis hipertensi. Reseptor adrenergik-α1 menyumbang kepada modulasi nada vaskular ginjal untuk mengawal tekanan darah. Hypertension is a major cause of morbidity and mortality from renal impairment. An increase of sodium intake contributes to the pathogenesis of hypertension. α1-adrenoceptors modulate renal vascular tone in the regulation of blood pressure. This study was undertaken to investigate the effects of tempol and losartan on renal function and haemodynamics in Sprague Dawley (SD) rats fed with normal diet, SD rats fed with high sodium diet, DOCA-salt treated rats fed with normal diet and DOCA-salt treated rats fed with high sodium diet.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
    Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
    Depositing User: Mr Firdaus Mohamad
    Date Deposited: 31 Mar 2017 10:24
    Last Modified: 31 Mar 2017 10:24
    URI: http://eprints.usm.my/id/eprint/32669

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