Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models

Harun, Norsyifa (2016) Studies Of Mitragynine, The Principle Alkaloid Of Mitragyna Speciosa Korth (Kratom) On Its Abuse And Addictive Properties In Rat Behavioural Models. PhD thesis, Universiti Sains Malaysia.

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    Abstract

    Mitraginina adalah alkaloid aktif utama yang dipencil daripada daun Mitragyna speciosa atau kratom. Sementara mitraginina atau kratom menghasilkan kesan-kesan analgesik, anti-radang dan relaksi otot, namun sedikit yang telah diketahui tentang sifat-sifat penyalahgunaan dan penagihannya. Diberikan kemungkinan kepentingan sistem opioid dalam perantaraan kesan-kesan farmakologi mitraginina, kajian ini bertujuan meninjau kesan-kesan tingkah laku daripada mitraginina menggunakan tatacara pendiskriminasian drug dan pemberian sendiri drug. Tikus jantan jenis Sprague Dawley telah dilatih untuk mendiskriminasi antara mitraginina dan pembawa menggunakan tatacara pendiskriminasian drug dua tuil di bawah pembolehubah selang secara tandem (VI-60 saat) dan nisbah tetap (FR-10) dalam jadual pengukuhan makanan. Tikus-tikus itu telah berjaya memperoleh pendiskriminasian mitraginina (15.0 mg/kg, i.p.) yang mirip dengan kumpulan tikus yang satu lagi dengan pendiskriminasian morfina (5.0 mg/kg, i.p.) Mitragynine is the main active alkaloid isolated from the leaves of Mitragyna speciosa or kratom. While mitragynine or kratom provides analgesic, anti-inflammatory and muscle relaxant effects, little is known about its abuse and addictive properties. Given the likely importance of opioid system in mediating the pharmacological effects of mitragynine, the present study aims to explore the behavioural effects of mitragynine using drug discrimination and drug self-administration procedures. Male Sprague Dawley rats were trained to discriminate between mitragynine and vehicle in two-lever drug discrimination procedure under a tandem variable-interval (VI-60 sec) and fixed-ratio (FR-10) schedule of food reinforcement. The rats successfully acquired mitragynine discrimination (15.0 mg/kg, i.p.) which was similar to another group of rats with morphine discrimination (5.0 mg/kg, i.p.).

    Item Type: Thesis (PhD)
    Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
    Divisions: Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research)
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 26 Jan 2017 17:21
    Last Modified: 26 Jan 2017 17:21
    URI: http://eprints.usm.my/id/eprint/31846

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