Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies

Liew , Kok Fui (2016) Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies. PhD thesis, Universiti Sains Malaysia.

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    Abstract

    Penyakit Alzheimer (AD) ialah penyakit kompleks pelbagai faktor melibatkan pelbagai mekanisme yang menyumbang kepada pencetusan penyakit ini. Dalam pencarian entiti kimia baru untuk menangani faktor-faktor penyebab penyakit ini, strategi rekaan ligan diarah pelbagai sasaran (MTDL) telah digunakan dalam kajian ini dengan menggabungkan motif struktur yang terpilih (pelbagai amina dan karbamat) daripada dua ubat Alzheimer yang mantap (donepezil dan rivastigmina) ke dalam perancah auron. Alzheimer’s disease (AD) is a complex multifactorial disease involving diverse mechanisms contributing to the onset of the disease. In the search for novel chemical entities to address the causative factors of the disease, the multitarget-directed ligand (MTDL) design strategy has been applied in the present study by incorporating selected structural motifs (various amines and carbamate) from two established Alzheimer drugs (donepezil and rivastigmine) into the aurone scaffold.

    Item Type: Thesis (PhD)
    Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
    Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
    Depositing User: Mr Firdaus Mohamad
    Date Deposited: 16 Jan 2017 14:31
    Last Modified: 22 Mar 2017 09:59
    URI: http://eprints.usm.my/id/eprint/31611

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