Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones

Lim , Sumithda Yeong Hui (2016) Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (NMR) dan mikroanalisis CHN. Analisa pembelauan sinar-X hablur tunggal (XRD) juga dijalankan dengan hablur bagi sebatian 3, 34, dan 41 menghablur dalam sistem kristal triklinik. Lima siri kalkon kemudiannya disintesis melalui kaedah kondensasi Claisen-Schmidt dengan tiga siri diterbitkan daripada kumarin asetil tertukar ganti (12-33) dan dua siri yang lain diterbitkan daripada asetofenon tertukar ganti (34-46). Semua kalkon yang disintesis telah dicirikan dengan analisa unsur (CHN), spektroskopi FTIR , 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC dan 1H-13C HMBC. Kalkon 23, 28, 34, dan 41 telah dipilih untuk analisis kristolografi. This study was started by the synthesis and characterization of two main series of starting materials: alkylation of naphthaldehydes (2-8) and acetylation of substituted coumarins (9-11). The starting materials thus obtained were elucidated by the spectroscopic methods such as fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and CHN microanalyses. Single crystal X-ray diffraction (XRD) analyses have also been carried out wherein the crystals of compound 3, 34 and 41 crystallized in a triclinic crystal system. Five novel series of chalcones were subsequently synthesized by means of Claisen-Schmidt condensation wherein three series were derived from substituted acetyl coumarins (12-33) and the remaining two series was derived from substituted acetophenones (34-46). All the synthesized chalcones were characterized by elemental analysis (CHN), FTIR, 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC spectroscopy. Selected chalcones, 23, 28, 34, and 41 were selected for crystallography analysis.

    Item Type: Thesis (Masters)
    Subjects: Q Science > QC Physics > QC1 Physics (General)
    Divisions: Pusat Pengajian Sains Fizik (School of Physics) > Thesis
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 04 Jan 2017 09:52
    Last Modified: 22 Mar 2017 10:23
    URI: http://eprints.usm.my/id/eprint/31375

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