Mohd Suhaimi, Ahmad Marwazi (2024) Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease. Masters thesis, Universiti Sains Malaysia.
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Abstract
AD begins with memory and cognitive impairment and progresses to speech and movement skills which affects 35% of 80-year-olds adult. According to the amyloid cascade hypothesis, two proteins which are Amyloid Precursor Protein (APP), and Presenilin 1 (PS1) play a vital role in contributing to AD. Mutated APP and PS1 are shown to be responsible for the production of pathogenic amyloid-beta (Aβ42) peptide in AD patient, which then forms Aβ42 plaques and deposited in the brain. Presenilin 1 (PS1) is the primary component of γ-secretase which catalyses the cleavage of APP (neuron development) especially at the beta region of APP in both amyloid pathways.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Aizat Asmawi Abdul Rahim |
| Date Deposited: | 13 Oct 2025 08:07 |
| Last Modified: | 13 Oct 2025 08:07 |
| URI: | http://eprints.usm.my/id/eprint/62948 |
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