Investigation of the potential of gelucire 44/14 for enhancing oral bioavailability using two model drugs [RS199.5. M211 2007 f rb].

Magosso, Enrico (2007) Investigation of the potential of gelucire 44/14 for enhancing oral bioavailability using two model drugs [RS199.5. M211 2007 f rb]. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Dua drug model yang termasuk dalam dua kumpulan Biopharmaceutics Classification System (BCS) yang berbeza, iaitu vancomycin (VCM), satu sebatian kelas III (keterlarutan tinggi dan ketelapan rendah), dan griseofulvin, satu drug kelas II (keterlarutan rendah and ketelapan tinggi) telah digunakan untuk menilai potensi satu pembawa gliserida berpoliglikol, iaitu Gelucire 44/14, untuk meningkatkan biokeperolehan oral. Two model drugs belonging to different groups of the Biopharmaceutics Classification System (BCS), which are vancomycin (VCM) as a class III drug (high solubility and low permeability) and griseofulvin (GF) as a class II drug (low solubility and high permeability), were employed to evaluate the potential of a polyglycolised glyceride carrier, namely Gelucire 44/14, to enhance their oral bioavailability.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
    Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy)
    Depositing User: Mr Erwan Roslan
    Date Deposited: 04 May 2009 11:40
    Last Modified: 13 Jul 2013 12:13
    URI: http://eprints.usm.my/id/eprint/9691

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