Formulation And Evaluation Of Rifampicin-Loaded Polymeric Particles For Pulmonary Delivery [RC311.4. J94 2006 f rb].

Abstract

Partikel polimerik dibangunkan menggunakan polimer bioterdegradasikan PLGA dan mPEG-DSPE. Pengaruh berbagai parameter formulasi ke atas ciri-ciri fisikal partikel polimerik dinilai. Parameter formulasi yang dinilai untuk PLGA ialah jenis polimer (RG 502, RG 503H dan RG 504), kepekatan PVA (2.5 dan 5 % w/v) dan perkadaran drug dengan polimer (0.2:1, 0.5:1 and 1:1). Polymeric particles were developed using PLGA and mPEG-DSPE biodegradable polymers. The influence of various formulation parameters on physical characteristics of polymeric particles was investigated. The formulation parameters investigated for PLGA were polymer type (RG 502, RG 503H and RG 504), PVA concentration (2.5 and 5 % w/v) and drug to polymer ratio (0.2:1,0.5:1 and 1:1).