Formulation And Evaluation Of Rifampicin-Loaded Polymeric Particles For Pulmonary Delivery [RC311.4. J94 2006 f rb].

Abdulla, Juma Masoud Abdulla (2006) Formulation And Evaluation Of Rifampicin-Loaded Polymeric Particles For Pulmonary Delivery [RC311.4. J94 2006 f rb]. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Partikel polimerik dibangunkan menggunakan polimer bioterdegradasikan PLGA dan mPEG-DSPE. Pengaruh berbagai parameter formulasi ke atas ciri-ciri fisikal partikel polimerik dinilai. Parameter formulasi yang dinilai untuk PLGA ialah jenis polimer (RG 502, RG 503H dan RG 504), kepekatan PVA (2.5 dan 5 % w/v) dan perkadaran drug dengan polimer (0.2:1, 0.5:1 and 1:1). Polymeric particles were developed using PLGA and mPEG-DSPE biodegradable polymers. The influence of various formulation parameters on physical characteristics of polymeric particles was investigated. The formulation parameters investigated for PLGA were polymer type (RG 502, RG 503H and RG 504), PVA concentration (2.5 and 5 % w/v) and drug to polymer ratio (0.2:1,0.5:1 and 1:1).

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
    Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy)
    Depositing User: ARKM Al Rashid Automasi
    Date Deposited: 25 Mar 2009 15:24
    Last Modified: 13 Jul 2013 11:57
    URI: http://eprints.usm.my/id/eprint/8634

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