Biochemical characterization of human and yeast choline and ethanolamine kinases [QD415. S451 2006 f rb].

Abstract

Kolina kinase (CK) dan etanolamina kinase (EK) merupakan enzim pertama di dalam biosintesis fosfatidilkolina dan fosfatidiletanolamina. Peningkatan aktiviti CK telah dikaitkan dengan tumor manusia. Oleh itu, perencatan CK telah dicadangkan sebagai strategi antikanser yang berpotensi. Choline kinase (CK) and ethanolamine kinase (EK) are the first enzymes in the biosynthesis of phosphatidylcholine and phosphatidylethanolamine. Increased activity of CK has been implicated in human tumors. CK inhibition has therefore been proposed as a potential anticancer strategy.