Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.

Syahrin, A. S. and Amrah, S. S. and Ghan, K. L. and Lim, B.Y. and Hasenan, N. and Hasnan, J. and Mohsins, S. J. (2006) Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. Int J Diab Ctries, 26 (4). pp. 163-168.

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    Abstract

    The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats. METHODOLOGY: Rats with regular estrous cycle (EC) prior to STZ induction were randomly divided into five groups. The normal (nondiabetic) and diabetic controlgroups were given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose (CMC) by gavagingl daily for 6 weeks. Other diabetic groups were treated with 50, 100 and 200 mg/kg/day of AP extracts respectively. The rats' body weight (BW), fasting blood glucose and insulin level were measured; and daily, EC evaluation was perfo;.ry1e.d1 throughout the 6-week study period. At the end.olthe experiment, rats were sacrificed and their P4fprpases were removed for histological examination."RESU LTS':, The survival rates and estrous cycle,'$f''AP-treatbd diabetic animals were found to be improved compared to nontreated animals.

    Item Type: Article
    Subjects: R Medicine > RB Pathology
    Divisions: Kampus Kesihatan (Medical Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences)
    Depositing User: Kiru Kirubananthan
    Date Deposited: 24 Feb 2009 16:23
    Last Modified: 13 Jul 2013 11:50
    URI: http://eprints.usm.my/id/eprint/8170

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