Design And Evaluation Of Prolonged Release Gliclazide Matrix Tablets.

Abstract

Tablet pelepasan terkawal matriks gliklazid disediakan dengan menggunakan bahan-bahan polymer, iaitu, HPMC, Kollidon SR, Carbopol dengan Xanthan gum, Eudragit RSPO dan Eudragit RLPO. HPMC, Kollidon SR dan Carbopol dengan Xanthan gum mampu merencat pelepasan gliklazid daripada tablet matriks dalam corak yang bergantung pada kepekatan, tetapi kadar perencatan adalah berbeza di antara polimer. The prolonged release gliclazide matrix tablets were prepared using polymeric materials, namely, HPMC, Kollidon SR, Carbopol with Xanthan gum, Eudragit RSPO and Eudragit RLPO. HPMC, Kollidon SR and Carbopol with Xanthan gum were able to retard gliclazide release from matrix tablets in a concentration dependent manner, but the rate of retardation differed among the polymers.