Silvaragi, Thayvee Geetha Bharathi (2025) Carcinogenic Analysis Of Heterocyclic Amines 2-Amino-1-Methyl-6-Phenylimidazo[4,5-B]Pyridine (Phip) And 2-Amino-3,8-Dimethylimidazo[4,5-F]Quinoxaline (Meiqx) Using Bhas 42 Cell Line. PhD thesis, Universiti Sains Malaysia.
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Abstract
Heterocyclic amines (HCAs) are common food carcinogens that are produced in cooked foods rich in protein at a high temperature. The present study investigates the carcinogenic effects of physiologically relevant concentrations of the two most commonly occurring HCAs, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), on Bhas 42 cells, a clone established from BALB/c3T3 A31-1-1 mouse fibroblast cells, a cell line strongly recommended by OECD for cancer studies due to its greater sensitivity towards oncogenic stimuli.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | Mr Aizat Asmawi Abdul Rahim |
| Date Deposited: | 26 Aug 2026 23:51 |
| Last Modified: | 26 Aug 2026 23:51 |
| URI: | http://eprints.usm.my/id/eprint/64845 |
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