Che Lamin, Roz Azinur (2025) Neuroprotective Effects Of Diterpenoids-Enriched Fraction Of Andrographis Paniculata And Andrographolide In Ischaemia-Induced Neuronal Death And Cognitive Impairment: In Vitro And In Vivo Models. PhD thesis, Universiti Sains Malaysia.
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Abstract
Andrographis paniculata (Burm.f.) Wall. ex Nees, known as “hempedu bumi”, has been studied for its cognitive-enhancing and neuroprotective effects. However, the study on the potential of A. paniculata diterpenoids-enriched fraction against learning and memory impairment is limited, particularly in vascular-pathology-related dementia. Thus, this study aimed to enhance the methanolic extract of A. paniculata via the enrichment of diterpenoids through a fractionation process and evaluate its cognitive-enhancing and neuroprotective effects along with andrographolide, the major diterpenoid of A. paniculata, using in vitro and in vivo models.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Aizat Asmawi Abdul Rahim |
| Date Deposited: | 19 Aug 2026 03:26 |
| Last Modified: | 19 Aug 2026 03:26 |
| URI: | http://eprints.usm.my/id/eprint/64795 |
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