Dam, V Sha Kri Eh (2022) Cross-reactivity of cockroaches to house dust mites and seafood in allergic rhinitis patients in Hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia.
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Abstract
Background: Allergic rhinitis (AR) is a common disease globally, mediated by type 1 immediate hypersensitivity response, with implication on quality of life and economic burden. Cockroach is an important aeroallergen that shows cross-reactivity with other inhalant and food allergens and contributes to the severity of AR. Objective: This study aimed to determine the prevalence of cockroach sensitization in AR patients, its cross-reactivity with house dust mite (HDM) and seafood, and to compare the severity of AR in response to cockroaches. Methods: This is a cross sectional study with involvement of 110 adult AR subjects. Skin prick test (SPT), and subsequently specific immunoglobulin E test were performed using direct enzyme-linked immunosorbent assay (ELISA) and cross-reactivity profile was obtained using indirect inhibition ELISA. Results: Majority of patients were Malay (95.5%), female (60.9%) with median age of 36.8 years. On SPT, HDM (93.6%) showed highest prevalence, followed by cockroach (51.8%) and seafood (40%). Lower percentage seen on direct ELISA but shared similar pattern of distribution (64.5%, 41.8% and 19.1% respectively). Cross-reactivity between cockroach and HDM was the most common, followed by between different species of cockroach and the least was between cockroach and seafood. Sensitization to cockroach demonstrated significant association with increase severity of AR (p < 0.05), however no difference in severity comparing the two different types of cockroaches (p > 0.05). Conclusion: Cockroach is an important aeroallergen with major contribution to severity of AR and has high cross-reactivity with HDM but lower cross-reactivity with food allergen (seafood) in our cross-sectional population.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | - |
| Subjects: | R Medicine R Medicine > RF Otorhinolaryngology |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis |
| Depositing User: | MUHAMMAD AKIF AIMAN AB SHUKOR |
| Date Deposited: | 28 Jul 2026 03:04 |
| Last Modified: | 13 Oct 2026 07:45 |
| URI: | http://eprints.usm.my/id/eprint/64731 |
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