Said @Fauzi, Agustine Nengsih (2014) Modulation of tamoxifen effects on era-positive and era-negative breast cancer cells by tualang honey. PhD thesis, Universiti Sains Malaysia.
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Abstract
Tamoxifen (TAM) is an anti-estrogen drug commonly used for treatment of hormone receptor-positive breast cancer. However, the side effects and cancer cell resistance to TAM limits its clinical efficacy. Therefore, many studies have been conducted to focus on the combination treatment of TAM with new agents or compounds to achieve the treatment objective with minimal side effects. For these reasons and based on the increasing reports of its medicinal use, Tua/ang honey (TH) was selected in this study. The current study aimed to evaluate the role of TH in modulating TAM effects and its death signalling pathways in human breast cancer cells, MCF-7 (ERa-positive) and MDA-MB-231 (ERa-negative) as well as in nonmalignant breast epithelial cells, MCF lOA. Initially, all cells were treated with TH to determine its cytotoxic effects and to identify the type of cell death mechanism. For further analyses, the cells were treated with TH, TAM and the combination of TH+ TAM for determination of apoptotic activity, alteration in mitochondrial membrane potential (
| Item Type: | Thesis (PhD) |
|---|---|
| Uncontrolled Keywords: | Breast neoplasms |
| Subjects: | R Medicine |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis |
| Depositing User: | Mr Abdul Hadi Mohammad |
| Date Deposited: | 19 Jul 2026 07:20 |
| Last Modified: | 19 Jul 2026 07:22 |
| URI: | http://eprints.usm.my/id/eprint/64674 |
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