SOW, EMMY (2018) Seroprevalence Of Hepatitis B In First- Time Blood Donors Of National Blood Centre After Implementation Of National Vaccination Programmе. Masters thesis, Universiti Sains Malaysia.
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png) |
PDF
Download (4MB) |
Abstract
Background: Malaysia's prevalence of hepatitis B is about 5% with the related mortality rate of 0.04 in 2013. Transmission preventive measures were implemented via national vaccination programme since 1989 with vaccine coverage of 99.3%. In Malaysia, universal blood donor screening for hepatitis B virus (HBV) using serology method was implemented since 1974 while nucleic acid testing (NAT) began since 2007 in National Blood Centre. Objective: To determine the seroprevalence of hepatitis B among first-time blood donors after implementation of national hepatitis B vaccination programme. Methods: A cross sectional study involving review of 215 Malaysian first time donors records that was screened positive for HBV and donated between 1st January 2010 to 31st December 2015 at National Blood Centre. Results: The overall prevalence of hepatitis B among the first-time blood donors of NBC from 1st January 2010 to 31st December 2015 was 0.15%. The prevalence of hepatitis B was higher at 0.23% among donors born before year 1989 (pre-vaccination era) compared to 0.05% among donors born in and after year 1989 (post-vaccination era). More donors born pre-vaccination era have known risk factors compared to the other group of donors. The stages of infection were highest for non-replicating followed by replicating and convalescence regardless year of birth. Among donors born pre-vaccination era, majority (97.2%) were HBsAg+, all were anti-HBc+, 30.3% were HBeAg+ and 71% were antiHBe+. For donors born post-vaccination era, 98.6% were HBsAg+ and anti-HBc+, 50% were HBeAg+ and 48.6% were antiHBe+. All donors were NAT+ irrespective of year of birth. There was significant association of the seroprevalence for HBeAg and anti-HBe with year of birth (p < 0.05). There was no association between stages of infection with risk factors and demographic characteristics of donors (p > 0.05). Conclusions: The prevalence of HBV among donors who received birth vaccination was lower than those who did not. Occult infection (anti-HBc+, NAT+ with HBsAg-) was also reduced in donors who received birth vaccination. Implementation of national vaccination programme for HBV infection has contributed to the reduction of HBV infection and in minimizing the risk of transfusion-related transmission.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 17 Jul 2026 02:02 |
| Last Modified: | 17 Jul 2026 02:02 |
| URI: | http://eprints.usm.my/id/eprint/64672 |
Actions (login required)
 |
View Item |
