Alwan Alogaili, Iqdam Abdulmaged (2018) Efficacy And Safety Of Annona Muricata L. As A Pharmaceutical Agent In Diabetes: A Systematic Review. Masters thesis, Universiti Sains Malaysia.
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Abstract
Diabetes is a metabolic disorder characterized by chronic hyperglycemia due to the absence or insufficient production of insulin. The use of medicinal plants in the management of diabetes is globally spread. Annona muricata L. is a plant of Annonaceae family and known to have antihyperglycemic effect. During the past few decades, numerous scientific investigations have been conducted on the antidiabetic effects of A. muricata and its safety effects. However, no comprehensive evidence-based systematic review regarding these topics is available. Hence, this review was aimed to summarize up-to-date and comprehensive studies on the antidiabetic activity, the possible mechanism of antidiabetic action and the possible toxic effects of A. muricata.Six online databases which were PubMed, Web of Science, Scopus, ScienceDirect, Google scholar, SpringerLink were used to systematically search for the related articles over the period of 2002 till April 2018. The search terms used were A. muricatal soursop/ graviola/ guanabana and diabetes, antihyperglycemia, glucose and toxicity/ safety. The final articles included in this review were twenty-four. Different parts of the plant extracts, particularly leaves showed significant effect on the antidiabetic parameters which include reduction of blood glucose, stimulation of insulin secretion and restoration of body weight and lipid profile. Further studies have elucidated the possible mechanisms of antidiabetic effect which includes improvement in antioxidant enzymes, reduction of lipid peroxidation, pancreas protective and hepatoprotective effects, as well as inhibition of carbohydrate metabolizing enzymes. On the hand, safety studies of A. muricata reported mixed findings. In vivo studies showed no toxic effect upon ingestion of pulp and seed extracts in rat models. On contrary, several in vitro studies have reported neurotoxicity and neurodegenerative effects of A. muricata and its isolated acetogenins and alkaloids. As a conclusion, A. muricata has a promising therapeutic effect against diabetes. However, further investigations are required to identify the active principles responsible for the antidiabetic effect and to determine the threshold value of these compounds at which this effect is caused before any clinical trial could be conducted. In vivo toxicity study on the effect of neurotoxins of A. muricata is also needed to verify their toxic effects on human.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 16 Jul 2026 01:03 |
| Last Modified: | 16 Jul 2026 01:03 |
| URI: | http://eprints.usm.my/id/eprint/64652 |
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